Saturday, August 7, 2010

mortality rates of patients with type 1 diabetes receiving renal replacement therapy

A European study with data from 10 national registries showed a decrease in the mortality rates of patients with type 1 diabetes receiving renal replacement therapy (RRT) during the time period 1991–2000 (7). In a Danish registry study that covered the time period 1990–2005, the overall survival rate of patients with diabetes receiving RRT had improved by 15% per 5 calendar years, but the survival rate of patients with type 1 diabetes was not assessed separately per time period (8). Moreover, registry data from Australia and New Zealand from 1991 to 2005 showed no significant change in the survival of patients with type 1 diabetes receiving RRT over time, although the survival of patients with type 2 diabetes as well as of that of patients without diabetes had improved (9). The authors also reported that the prognosis of patients with type 1 diabetes remained poor regardless of good access to kidney transplantation. Taken together, despite continuous advances in the management of diabetes and the prevention of diabetic nephropathy, there are only scarce data on whether the prognosis of patients with type 1 diabetes receiving RRT has improved.
Descriptive results
The patients with type 1 diabetes showed a significant increase in median age and an overall decrease in peritoneal dialysis mode. The initial RRT mode was hemodialysis in 46.1%, peritoneal dialysis in 53.5%, and kidney transplantation (preemptive) in 0.4%. Sex distribution remained the same with two-thirds being men. The probability to receive a kidney transplant within 2 years from the RRT start diminished from 60% in 1980–1984 to 35% in 2000–2005 (Table 1).
Crude survival of patients with type 1 diabetes
Of the 1,604 patients with type 1 diabetes, 1,047 (65.3%) had died, and 557 patients were censored (alive at the end of follow-up on 31 December 2007, n = 548; regained own kidney function, n = 5; moved abroad, n = 4; and lost to follow-up, n = 0). Cardiovascular causes remained the main cause of death and comprised 65.8% of deaths (Table 1). Median survival time increased throughout the span of our study, from 3.60 years (95% CI 2.50–4.70) to 7.24 (95% CI 5.74–8.74) from the time period 1980–1984 to 1995–1999 (Fig. 1). Median survival time of patients starting RRT during 2000–2005 could not be calculated because it was longer than the maximal follow-up time, thus indicating a median survival time of >8 years. The median survival times increased significantly in all of the age-groups (Fig. 2). The absolute risk of death within 5 years from the start of RRT dropped from 51% in 1980–1984 to 33% in 2000–2005. The unadjusted relative risk (RR) of death was 0.55 for patients that entered RRT in 2000–2005 compared with those that entered in 1980–1984 (Table 2). In the different age-groups the corresponding RRs were even lower, varying between 0.31 and 0.38, indicating a confounding effect of age. In univariate analysis, the risk of death increased by 4.1% (95% CI 3.4–4.7%) per year of age at the start of RRT. Sex was not associated with risk of death (P = 0.360). Patients having hemodialysis as the initial mode of RRT had 1.4-fold risk (95% CI 1.2–1.6) of death compared with patients that entered peritoneal dialysis. Death risk was much higher in patients who did not receive a kidney transplant within 2 years
We observed a considerably improved prognosis of patients with type 1 diabetes receiving RRT since 1980. The RR of death was 77% lower for patients beginning RRT in 2000–2005 compared with 1980–1984. Our results are based on a nationwide database with long-term coverage of all dialysis and kidney transplant patients in Finland. To our knowledge, our study is the first to show improvement in the prognosis of patients with type 1 diabetes receiving RRT during a follow-up as long as 28 years.
Interestingly, our study shows a progressive increase in median survival time of patients with type 1 diabetes receiving chronic RRT from 3.60 to >8 years and with similar survival improvement across all age-groups and throughout the follow-up period 1980–2007 (Fig. 2). Our results are in line with the observations of Sørensen et al. (8), who found that the overall survival rate of ESRD patients with type 1 or type 2 diabetes had improved by 15% per 5 calendar years. Our findings are also in accordance with an earlier European study by van Dijk et al. (7) that included a larger number of patients with ESRD but had a markedly shorter follow-up time, in which there was only a modest age- and sex-adjusted 2-year mortality reduction for all patients with type 1 diabetes, but a more pronounced 49% reduction in those patients that received a kidney transplant comparing years 1991–1994 to 1995–1998. Our study, however, is the first focusing only on patients with type 1 diabetes and expanding the observation period to almost three decades.
It is noteworthy that the prognosis in this cohort improved over time despite the fact that some patient characteristics were changing in a direction that should be unfavorable with regard to prognosis. In particular, the median age of patients with type 1 diabetes increased by nearly 10 years over the duration of our study period, and the glomerulonephritis group aged to an even greater extent. The proportion of elderly subjects increased in both groups. Mean age of patients at the time of type 1 diabetes diagnosis, however, has not changed, but the time before development of ESRD has increased (5). We also observed a diminishing proportion of patients starting peritoneal dialysis, which is the treatment mode that correlated with the better prognosis. Moreover, the probability of receiving a kidney transplant declined clearly. Thus, the improved prognosis could possibly be explained by better overall management of the patients with chronic kidney disease before and during RRT, as well as by developments in dialysis techniques and diabetes care.
During the follow-up time of our study, the number of patients with type 1 diabetes starting RRT in Finland has increased from 205 in 1980–1984 to 440 in 2000–2005. Their relative proportion, however, out of all patients starting RRT has decreased progressively from 22 to 15%. Despite the decreasing relative incidence, the relative prevalence of patients with type 1 diabetes of all patients receiving RRT has remained constant at ∼17%. This confirms the improved survival of patients with type 1 diabetes receiving RRT as shown in our current study.
To estimate the possible effect of progress in diabetes care, we chose patients with glomerulonephritis as the control group because it is obvious that among patients with glomerulonephritis an improved prognosis could not be caused by better diabetes care. Furthermore, we excluded patients with systemic glomerulonephritis because they could be regarded as potentially sicker than patients with disease affecting only the kidneys. We found a more substantial survival benefit over time for patients with type 1 diabetes compared with patients with glomerulonephritis, indicating that advances in diabetes care and management of diabetes complications may have partly contributed to our observation of improved prognosis of patients with type 1 diabetes.
Over the last few decades, management of diabetes has evolved remarkably in terms of insulin regimens and more intensive blood glucose monitoring. Disposable insulin syringes became widely available in the early 1970s, and home glucose monitoring and semisynthetic and synthetic human insulin reached wider use in the 1980s. With the emergence of multiple insulin injections in the 1990s followed by the development of rapid-acting insulin regimens, patients with type 1 diabetes were able to maintain more stable blood glucose control and closer-to-target A1C levels. In our study population, however, the level of A1C has shown only slight changes during the past years: the mean value was 8.4% in 1992 (when these data were routinely gathered for the first time) and was almost the same in 2007 (8.0%). Nevertheless, this finding does not exclude other potential improvements such as fewer hypo- and hyperglycemic events, with probable beneficial effects on mortality. By taking into account the obvious developments in diabetes care, it is likely that the level of A1C was higher in the 1980s, thus increasing the likelihood of a negative outcome in these patients.
On the other hand, quality and dose of dialysis therapy have also improved over the years. During the 1980s most hemodialysis patients were treated with basic techniques and low-flux cellulosic dialyzers, with no access to on-line hemodiafiltration or modern synthetic high-flux dialyzers with better biocompatibility. Use of these has been expanding since the mid-1990s, allowing enhanced uremic toxin clearance and flexibility of hemodialysis treatment. With peritoneal dialysis therapy, the present availability of biocompatible fluids with better tolerability and solute removal and icodextrin-containing fluid (with superior ultrafiltration capability without excess glucose load) has increased the efficacy of peritoneal dialysis. In addition, the number of patients receiving peritoneal dialysis using automated overnight peritoneal dialysis machines has increased, leading to 1) greater toxin clearance, 2) better adjustment of peritoneal dialysis to everyday life with improved adherence and overall patient compliance to therapy, and 3) possibly diminished peritonitis episodes (10,11). In our patient population with type 1 diabetes, the mean number of weekly hemodialysis sessions increased from 2.9 (95% CI 2.8–3.0) to 3.1 (95% CI 3.0–3.3) from 1992 to 2007, with mean weekly treatment hours rising from 11.4 (95% CI 10.9–12.0) to 13.5 (95% CI 12.8–14.2). During the same time the percentage of those patients with type 1 diabetes who entered peritoneal dialysis therapy and initially used an automated machine rose from 2 to 27. It is a well-known fact that achieving target uremic toxin clearance improves survival in patients receiving dialysis (12), and thus the increase in dialysis dose could have led to improved survival in our study population. The dialysis dose, however, was approximately the same both for the patients with type 1 diabetes and patients with glomerulonephritis, suggesting that any survival advantage related to progress in dialysis technology should be similar in both groups.
It could also be speculated that patients with type 1 diabetic nephropathy are in more intensive monitoring by health care professionals compared with patients without diabetes. Patients with type 1 diabetes are closely followed up from childhood with routine visits to the health care system, which probably have preventive effects on cardiovascular complications (13). The comprehensive management of patients approaching ESRD includes control of blood pressure and calcium-phosphorus level and treatment with erythropoiesis-stimulating agents, which are known to have an effect on cardiovascular outcomes (14). However, in acknowledging that ∼66% of those patients with type 1 diabetes who died during our study period died of cardiovascular causes, there is a need for further studies to explore how comorbidities and other related factors before and during ESRD influence the outcome of patients receiving RRT.
Our study has some limitations. First, the results might not be generalizable to other countries, as the incidence of type 1 diabetes is among the highest in the world in Finland. Therefore, much attention has been focused on improving quality of diabetes care, which may explain part of the favorable progress in prognosis of the Finnish patients. Second, for most of the patients with type 1 diabetes we did not have kidney biopsy confirmation of the diagnosis because the long-term practice in Finland is to perform a biopsy only in rare patients when other microvascular, diagnosis-confirming findings are absent. Third, we did not have data on patient level details of diabetes treatment (e.g., type of insulin or type of blood pressure medication) or dialysis treatment (e.g., type of vascular access). Thus, we do not exactly know which aspects of treatment improvement have been responsible for the improved prognosis. On the other hand, the strength of the study is that it is based on an exceptionally comprehensive nationwide database with complete coverage of Finnish patients with ESRD. This excludes selection bias and allows longer follow-up of patients with type 1 diabetes receiving RRT than published before.
In summary, the survival of Finnish patients with type 1 diabetes and ESRD has consistently and significantly improved since the beginning of the 1980s despite the progressively older age of patients starting RRT. During the same time period, survival in the control group (patients with glomerulonephritis) has also improved but to a lesser extent. This result indicates a beneficial contribution of both dialysis-related factors and progress in diabetes care and highlights the importance of comprehensive diabetes care in patients receiving chronic renal replacement therapy.